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Decreased natural killer activity in patients with liver cirrhosis

✍ Scribed by Tatsuya Nakamura; Toshio Morizane; Tetsu Watanabe; Kanji Tsuchimoto; Yasutaka Inagaki; Naoki Kumagai; Masaharu Tsuchiya

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
316 KB
Volume
32
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Natural killer (NK) activity of peripheral blood mono‐nuclear cells from patients with non‐alcoholic liver cirrhosis (LC) (30 cases), patients with other, non‐malignant diseases (41 cases), and healthy subjects (36 cases) were investigated using ^51^Cr‐labelled CCRF‐CEM and K562 target cells. NK activity in patients with LC was lower than that in healthy subjects and that in patients with other, non‐malignant diseases. The differences were statistically significant by Student's t‐test and the Wilcoxon rank test. There was no difference of NK activity between serologically hepatitis B surface antigen (HB~s~Ag)‐positive and ‐negative patients.

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