Decreased myeloperoxidase expressing cells in the aged rat brain after excitotoxic damage
β Scribed by Oscar Campuzano; Maria del Mar Castillo-Ruiz; Laia Acarin; Berta Gonzalez; Bernardo Castellano
- Book ID
- 113615516
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 934 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0531-5565
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## Abstract In order to evaluate proinflammatory cytokine levels and their producing cell types in the control aged rat brain and after acute excitotoxic damage, both adult and aged male Wistar rats were injected with NβmethylβDβaspartate in the striatum. At different survival times between 6 hr an
Interleukin-1 beta (IL-1β€) has been proposed as a mediator of several forms of brain damage, including that induced by excitotoxins. In vitro studies suggest that glial cells are the effector cells of IL-1β€-mediated neurodegeneration. We have investigated the expression of IL-1β€ protein by glial cel