Decreased muscle loading delays maturation of the tendon enthesis during postnatal development

✍ Scribed by Stavros Thomopoulos; Hyun-Min Kim; Stefan Y. Rothermich; Carrie Biederstadt; Rosalina Das; Leesa M. Galatz

• Publisher: Elsevier Science
• Year: 2009
• Tongue: English
• Weight: 32 KB
• Volume: 27
• Category: Article
• ISSN: 0736-0266
• DOI: 10.1002/jor.20820

✦ Synopsis

The correct description of dosage is: A supraspinatus intramuscular injection of botulinum toxin A (BOTOX, Allergan Inc.) was made to the left shoulder of each mouse within 24 hours of birth. The supraspinatus muscle of the right shoulder was injected with an equal volume of saline to serve as a contralateral control. Based on our pilot studies, 0.2 U of botulinum toxin A diluted in 10 mL of phosphate buffered saline was injected intramuscularly using a 30 gauge needle. This dose is equivalent to 100U/Kg of body weight for a neonatal mouse that weighs 2 grams (on average) and to 8U/Kg of body weight for a 56-day-old mouse that weighs 25 grams (on average). Injections were repeated twice a week for the first 28 days and once a week thereafter. The dosage used and the frequency of injection was necessary to maintain paralysis without systemic side effects in the growing animals.

The article to which this Erratum refers appears in Volume 25, Number 9, pages 1154-1163.