Decreased lymphocyte reactivity to a suboptimal concentration of phytohemagglutinin in sjögren's syndrome
✍ Scribed by Joseph P. Michalski; Candace Mccombs
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 546 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0004-3591
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## Abstract Using monoclonal antibodies to cell surface antigens, we studied lymphocyte subsets in 15 patients with primary Sjögren's syndrome. The absolute number of OKT8‐positive cells (reactive with T suppressor/cytotoxic cells) was significantly decreased in such patients (353 ± 186/mm^3^) comp
Sjögren's syndrome (SS) is a systemic autoimmune disorder with a strong tumor predisposition (a 44-fold elevated incidence of non-Hodgkin's lymphoma has been reported). By polymerase chain reaction analysis of t(14;18), a key lymphomagenic event in peripheral blood lymphocytes, we found a lower freq
Drs. Pauley and Cha are coinventors with the University of Florida on a patent (University of Florida ID 13439) for a novel carbachol-siRNA conjugate that can be used as a vehicle for altering molecular signals in salivary epithelial cells in patients with Sjo ¨gren's syndrome.