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Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells

✍ Scribed by Stirewalt, D L; Choi, Y E; Sharpless, N E; Pogosova-Agadjanyan, E L; Cronk, M R; Yukawa, M; Larson, E B; Wood, B L; Appelbaum, F R; Radich, J P

Book ID
109886532
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
138 KB
Volume
23
Category
Article
ISSN
0887-6924

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## Abstract Hematopoietic cancer stem cells preserve cellular hierarchy in a manner similar to normal stem cells, yet the underlying regulatory mechanisms are poorly understood. It is known that both normal and malignant stem/progenitor cells express CD34. Here, we demonstrate that several cell lin