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Decreased half life of cyclophosphamide in patients under continual treatment

✍ Scribed by Maurizio D'Incalci; Giorgio Bolis; Terenzio Facchinetti; Costantino Mangioni; Luciano Morasca; Paolo Morazzoni; Mario Salmona

Book ID
113146317
Publisher
Elsevier Science
Year
1979
Weight
273 KB
Volume
15
Category
Article
ISSN
0014-2964

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The elimination half-life of lithium was investigated in 55 patients on long-term treatment in 1980, when their mean treatment time was 7.5 years. Twenty-seven of the patients were reinvestigated 7 years later, at which point their mean treatment time was 15 years. An approximate method for determin