Decreased frequency of HLA-DRB 1*13 alleles in Frenchwomen with HPV-positive carcinoma of the cervix
✍ Scribed by Xavier Sastre-Garau; Marie-Noelle Loste; Anne Vincent-Salomon; Michel Favre; Emmanuelle Mouret; Anne de la Rochefordiere; Jean-Claude Durand; Eric Tartour; Virginia Lepagi; Dominique Charron
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 676 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Specific types of human papillomaviruses (HPV) are associated with most cases of pre-invasive and invasive neoplasia of the uterine cervix. HLA phenotype influences susceptibility and resistance to viral infections and may therefore influence the course of HPV-associated tumors. Some data suggest that specific HLA class-ll alleles may be associated with protection from or susceptibility to papillomavirus-associated lesions, but these results are still controversial. Using molecular probes, we looked for associations between specific DQA I, DQ6 I, DR6 I HLA class-ll alleles, HPV types and cervical cancer. The analysis was performed on a population of 126 patients with invasive cervical cancer. For HLA typing, I65 healthy individuals were taken as controls. The DRB I * I30 I /02 allele frequency significantly decreased in patients (I I O h ) as compared to controls (29%). This difference in frequency was dependent on the HPV-positive status of tumors and was no longer significant in the group of HPV-negative lesions. The same trends were observed with the DR6 i * I301 102-DQA I *Of 03-DQ6 i *0603 haplotype frequency. An increase in the frequency of the DRB I * I40 I /07 and DRB I *03 alleles was observed in patients under 40. Contrary to what has been reported in the literature, no increase in the DRB I * I S allele frequency was observed in our series and only a slight increase in the DQ61*03 frequency was found in patients (7O0h) compared to controls (58%). In our study, no positive correlations between cervical cancer in Frenchwomen and specific HLA DR-DQ haplotypes has been found. In contrast, a negative correlation between DR6 I * 130 I I 02 alleles and HPV-positive tumors has been observed. This may suggest a protective effect of DR13 against HPV-associated lesions of the cervix.