Decreased Fragile X Mental Retardation Protein Expression Underlies Amygdala Dysfunction in Carriers of the Fragile X Premutation
β Scribed by David Hessl; John M. Wang; Andrea Schneider; Kami Koldewyn; Lien Le; Christine Iwahashi; Katherine Cheung; Flora Tassone; Paul J. Hagerman; Susan M. Rivera
- Book ID
- 119198979
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 664 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0006-3223
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## Abstract Older male premutation carriers of the __FMR1__ gene are associated with the risk of developing a lateβonset neurodegenerative disorder, fragile Xβassociated tremor/ataxia syndrome. Although previous postmortem and in vivo magnetic resonance imaging studies have indicated white matter p
Fragile X mental retardation results from the absence of a selective RNA-binding protein, FMRP. Previous studies demonstrated that FMRP forms messenger ribonucleoprotein (mRNP) complexes to associate with translating polyribosomes, suggesting that FMRP is involved in regulating protein synthesis. We