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Decreased expression of the ligand for CD40 in newborn lymphocytes

✍ Scribed by Ramsay Fuleihan; Deborah Ahern; Raif S. Geha

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
416 KB
Volume
24
Category
Article
ISSN
0014-2980

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## Abstract A major feature of the immature immune system in the newborn is its inability to produce significant levels of immunoglobulins other than IgM in response to antigens. It has recently been demonstrated that interaction of the CD40 molecule on B cells with the CD40 ligand (CD40L) on activ

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## Abstract ## BACKGROUND CD31 (platelet endothelial cell adhesion molecule‐1 [PECAM‐1]) is the ligand for CD38, a transmembrane glycoprotein that is expressed on the surface of leukemic cells in many patients with B‐cell chronic lymphocytic leukemia (B‐CLL). In a previous study, the authors showe