## Abstract Neuroblastoma, the most common extracranial solid tumor in children, arises from precursors of the sympathetic nervous system. Neuroblastoma cell lines are responsive to the differentiation agent retinoic acid, which induces its effects by altering transcription rates of specific target
β¦ LIBER β¦
Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
β Scribed by Thiele, Carol J.; Reynolds, C. Patrick; Israel, Mark A.
- Book ID
- 109737961
- Publisher
- Nature Publishing Group
- Year
- 1985
- Tongue
- English
- Weight
- 503 KB
- Volume
- 313
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/313404a0
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## Abstract To investigate the alteration of nuclear matrix proteins (NMPs) during the differentiation of neuroblastoma SKβNβSH cells induced by retinoic acid (RA), differentiation markers were detected by immunocytochemistry and NMPs were selectively extracted and subjected to twoβdimensional gel