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Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse

✍ Scribed by Xin Yan; Jan Lukas; Martin Witt; Andreas Wree; Rayk Hübner; Moritz Frech; Rüdiger Köhling; Arndt Rolfs; Jiankai Luo

Book ID
106461135
Publisher
Springer
Year
2011
Tongue
English
Weight
743 KB
Volume
26
Category
Article
ISSN
0885-7490

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## Abstract Niemann‐Pick C (NPC) disease is an autosomal recessive, lethal, neurodegenerative disorder caused by mutations in __NPC1__. By using the glial fibrillary acidic protein (GFAP) promoter, we demonstrated previously that astrocyte‐specific expression of __Npc1__ decreased neuronal storage