Decreased expression of filaggrin in atopic skin
β Scribed by Tokuji Seguchi; Cui Chang-Yi; Shigeru Kusuda; Masae Takahashi; Kinue Aisu; Tadashi Tezuka
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 279 KB
- Volume
- 288
- Category
- Article
- ISSN
- 0340-3696
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Background: Pediatric inflammatory bowel disease (IBD) has a high prevalence of coexistent atopy. Filaggrin (FLG) loss-of-function variants (null-alleles) are associated with eczema and asthma in association with eczema. The aim was to assess the contribution of FLG null-alleles to pediatric IBD sus
We studied lymphocyte proliferation and subsets in ten atopic dermatitis (AD) patients and ten healthy controls. In addition, monocyte production of interleukin 1 (IL-1) was investigated. Mean numbers of total T cells, T-cells subsets, and B cells did not significantly differ between AD patients and