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Decreased Drug Accumulation and Increased Tolerance to DNA Damage in Tumor Cells with a Low Level of Cisplatin Resistance

โœ Scribed by Cinzia Lanzi; Paola Perego; Rosanna Supino; Simona Romanelli; Tiziana Pensa; Nives Carenini; Ilario Viano; Donato Colangelo; Roberto Leone; Piero Apostoli; Giuliana Cassinelli; Romolo A Gambetta; Franco Zunino


Book ID
119407513
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
475 KB
Volume
55
Category
Article
ISSN
0006-2952

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## Multidrug -resistance (MDR) is characterized by the presence of a 170 kDa glycoprotein (P-glycoprotein) in the plasma membrane. P-glycoprotein is thought to act as an efflux pump, leading to reduced drug accumulation in MDR cells. This defect in drug accumulation can be overcome by membrane tra