Decreased DNA repair activity in sunburn cells

✍ Scribed by Wilhelm Brenner; Fritz Gschnait

• Book ID: 104763935
• Publisher: Springer-Verlag
• Year: 1979
• Tongue: English
• Weight: 967 KB
• Volume: 266
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00412857

✦ Synopsis

The pathogenesis of the formation of sunburn cells is unknown. Based on autoradiographic methods the unscheduled DNA repair synthesis of UV-induced thymin dimers was investigated in vivo in sunburn cells and in irradiated but histologically normal stratum spinosum cells. The results show a significant lower number of sparsly labeled cells in the sunburn cell-population (13.2 +/- 2.5; mean) when compared to the population of normal stratum spinosum cells (57.8 +/- 7.5; mean). These data indicate that the population of those epidermal cells, which become manifest as sunburn cells 24 h after UV exposure exhibit a reduced DNA repair of UV induced thymine dimers immediately after UV irradiation. Nuclear factors thus seem to play at least some role in the origin of sunburn cells.