Decreased cerebrospinal fluid levels of β-endorphin in Japanese patients with Joseph disease

✍ Scribed by Dr. Toyojiro Matsuishi; Tetsuo Sakai; Shinichiro Nagamitsu; Hironori Komori; Hiroshi Iwashita; Hiroshisa Kato

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 307 KB
• Volume: 36
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.410360317

✦ Synopsis

We measured the cerebrospinal fluid (CSF) levels of (3endorphin in 7 Japanese patients with Joseph disease and compared them with control values. The 7 patients included 4 with type I and 3 with type I1 disease; their mean age was 45.7 & 12.03 years. Diseased controls were matched in age to the patients studied. In these patients, CSF P-endorphin level was significantly lower than in the controls (40% of normal values). An alteration in CSF P-endorphin level may explain some of the neurological impairment found in Joseph disease.