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Decreased benzodiazepine receptor binding in epileptic El mice: A quantitative autoradiographic study

✍ Scribed by Yukiyoshi Shirasaka; Masatoshi Ito; Hideo Tsuda; Hideyuki Shiraishi; Katsuhiko Oguro; Kozoh Mutoh; Haruki Mikawa


Book ID
105017989
Publisher
Springer
Year
1990
Tongue
English
Weight
807 KB
Volume
15
Category
Article
ISSN
0364-3190

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✍ R. d'Argy; A. Persson; G. Sedvall πŸ“‚ Article πŸ“… 1987 πŸ› Springer 🌐 English βš– 791 KB

3H-Ro 15-1788, a benzodiazepine receptor antagonist, was injected IV into male and pregnant mice. Autoradiograms were prepared from sagittal sections of animals killed after 30 s to 48 h. In the adult animal there was a rapid and high initial accumulation of radioactivity in the brain as compared to