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Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer’s disease

✍ Scribed by Sylvain Doré

Book ID
114275126
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
60 KB
Volume
32
Category
Article
ISSN
0891-5849

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## Abstract Machado‐Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by polyglutamine expansion in the ataxin‐3 protein that confers a toxic gain of function. Because of the late onset of the disease, we hypothesize that the accumu