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Decrease of human pancreatic cancer cell tumorigenicity by A1,3galactosyltransferase gene transfer

✍ Scribed by Aubert, Muriel; Crotte, Christian; Bernard, Jean-Paul; Lombardo, Dominique; Sadoulet, Marie-Odile; Mas, Eric


Book ID
122061382
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
181 KB
Volume
124
Category
Article
ISSN
0016-5085

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## Abstract The enzyme Ξ±1,3galactosyltransferase synthesizes the Ξ±Gal epitope, a carbohydrate structure (GalΞ±1,3GalΞ²1,4GlcNAc‐R), on glycoconjugates in lower mammals. The enzyme is absent in humans but large amounts of natural antibodies that recognize Ξ±Gal epitopes are present in human serum. It i

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## Background: In previous reports, we used microcell fusion-mediated chromosomal transfer to introduce normal human chromosomes into highly metastatic rat prostatic cancer cells to map the location of tumor and metastasis suppressor genes. the gene for prostate-specific antigen as well as several