Decrease of extracellular catecholamine content in the vicinity of cortical penicillin-induced epileptogenic focus: voltammetric study in the rat

✍ Scribed by J. Pavlásek; P. Mareš; M. Haburčák; C. Mašánová

• Book ID: 104673372
• Publisher: Springer-Verlag
• Year: 1994
• Tongue: English
• Weight: 453 KB
• Volume: 98
• Category: Article
• ISSN: 0014-4819
• DOI: 10.1007/bf00229113

✦ Synopsis

Differential pulse voltammetry with carbon-fibre microelectrodes was used in chloralhydrate-anaesthetized rats to test the influence of the penicillin-G-Na (PNC)-induced (topical application, approximately 2000 IU) epileptic activity on the catecholamine content (catechol-oxidative current, CA.OC) in the parietal cortex. In the experimental group (n = 4) after PNC a nonlinear CA.OC lowering was observed; this decrease during the first 10 min was faster than in the control group (n = 4). Significantly different values were observed from the 4th min after application. The best fit for this experimental curve gave the logarithmic function (f(t) = a+b.ln(t), a = 105.8, b = -10.6) with regression coefficient r = 0.98. From the 12th min after PNC application until the end of the experiments (54th min) CA.OC values ranged from 78% to 84% of the control group.