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Decrease in insulin binding to aortic endothelial cells cultured with high glucose concentration

โœ Scribed by Ono, Hiroshi; Umeda, Fumio; Inoguchi, Toyoshi; Ibayashi, Hiroshi


Book ID
122419485
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
422 KB
Volume
6
Category
Article
ISSN
0168-8227

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In an attempt to identify the mechanisms underlying the ill effects of high glucose previously described in cultured human endothelial cells, we have investigated in these cells the activity of the polyol pathway and accumulation of glucose 6-phosphate, a powerful agent of non-enzymatic glycosylatio