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Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD67 protein

✍ Scribed by Graeme F Mason; David L Martin; Sandra B Martin; David Manor; Nicola R Sibson; Anant Patel; Douglas L Rothman; Kevin L Behar


Book ID
113997403
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
512 KB
Volume
914
Category
Article
ISSN
0006-8993

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Elevated endogenous GABA level correlate
✍ Zhengguang Chen; Afonso C. Silva; Jehoon Yang; Jun Shen πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 278 KB

## Abstract Vigabatrin and gabaculine, both highly specific inhibitors of GABA (γ‐aminobutyric acid) transaminase, cause significant elevation of endogenous GABA levels in brain. The time course of GABA concentration after acute GABA transaminase inhibition was measured quantitatively in the α‐chlo