## Abstract Chemotherapy and radiation treatment of the central nervous system may cause delayed neurotoxicity in children with acute lymphocytic leukemia. We evaluated 12 longβterm survivors of childhood leukemia using [^18^F]fluorodeoxyglucose positron emission tomography, computed tomography sca
Decrease in cerebral metabolic rate of glucose after high-dose methotrexate in childhood acute lymphocytic leukemia
β Scribed by Komatsu, Kazuo; Takada, Goro; Uemura, Kazuo; Shishido, Fumio; Kanno, Iwao
- Book ID
- 122743716
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 303 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0887-8994
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## BACKGROUND. Cranial radiation therapy (CRT) has been suggested to be a principal factor responsible for long term neurocognitive deficits in survivors of acute lymphoblastic leukemia (ALL). However, neither reduction of the irradiation dose nor the elimination of irradiation entirely appear to h
Six hundred thirty-four children with acute lymphoblastic leukemia (ALL) were randomized to receive sanctuary therapy consisting of either cranial irradiation (CRT) plus intrathecal (IT) methotrexate (MTX) or three courses of intermediate-dose methotrexate (IDM) plus intrathecal methotrexate. Two hu