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Decrease in 4-Aminobiphenyl-Induced Methemoglobinemia in Cyp1a2(−/−) Knockout Mice

✍ Scribed by Howard G. Shertzer; Timothy P. Dalton; Glenn Talaska; Daniel W. Nebert

Book ID
112268568
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
115 KB
Volume
181
Category
Article
ISSN
0041-008X

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## Abstract Cigarette smoking is the predominant risk factor for bladder cancer. Aromatic amines such as 4‐aminobiphenyl (ABP) is the major carcinogens found in tobacco smoke. Although it is generally accepted that ABP is metabolically activated __via__ __N__‐hydroxylation by CYP1A2 in human liver,