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(De)constructing the Ryanodine Receptor: Modeling Ion Permeation and Selectivity of the Calcium Release Channel

✍ Scribed by Gillespie, Dirk; Xu, Le; Wang, Ying; Meissner, Gerhard

Book ID
127122903
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
305 KB
Volume
109
Category
Article
ISSN
0022-3654

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✍ Andrew R. Marks; Silvia Priori; Mirella Memmi; Kimmo Kontula; Päivi J. Laitinen 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 177 KB

## Abstract The cardiac ryanodine receptor (RyR2), the major calcium release channel on the sarcoplasmic reticulum (SR) in cardiomyocytes, has recently been shown to be involved in at least two forms of sudden cardiac death (SCD): (1) Catecholaminergic polymorphic ventricular tachycardia (CPVT) or