Decoding Neural Circuit Structure and Function : Cellular Dissection Using Genetic Model Organisms

✍ Scribed by Çelik, Arzu; Wernet, Mathias F

Publisher: Springer
Year: 2017
Tongue: English
Leaves: 516
Series: SpringerLink : Bücher
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes.

Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden

tified circuit elements contribute to visual perception and behavior.

✦ Table of Contents

Front Matter ....Pages i-xiii
Front Matter ....Pages 1-1
The Current State of the Neuroanatomy Toolkit in the Fruit Fly Drosophila melanogaster (Daryl M. Gohl, Javier Morante, Koen J.T. Venken)....Pages 3-39
Retinal Connectomics (Kevin L. Briggman)....Pages 41-62
Recent Progress in the 3D Reconstruction of Drosophila Neural Circuits (Kazunori Shinomiya, Masayoshi Ito)....Pages 63-89
Connectivity and Circuit Architecture Using Transsynaptic Tracing in Vertebrates (Kazunari Miyamichi, Lindsay A. Schwarz)....Pages 91-148
Live Imaging of Connectivity in Developing Neural Circuits in Drosophila (Mehmet Neset Özel, Peter Robin Hiesinger)....Pages 149-167
Front Matter ....Pages 169-169
Manipulation of Neural Circuits in Drosophila Larvae (Ibrahim Tastekin, Matthieu Louis)....Pages 171-189
Targeted Manipulation of Neuronal Activity in Behaving Adult Flies (Stefanie Hampel, Andrew M. Seeds)....Pages 191-222
Paradigms for the Quantification of Behavioral Responses in Zebrafish (Chiara Cianciolo Cosentino, Stephan C. F. Neuhauss)....Pages 223-239
The Use of Computational Modeling to Link Sensory Processing with Behavior in Drosophila (Jan Clemens, Mala Murthy)....Pages 241-260
Motor-Driven Modulation in Visual Neural Circuits (Terufumi Fujiwara, Eugenia Chiappe)....Pages 261-281
Causal Circuit Explanations of Behavior: Are Necessity and Sufficiency Necessary and Sufficient? (Alex Gomez-Marin)....Pages 283-306
Front Matter ....Pages 307-307
Visualization of Synapses and Synaptic Plasticity in the Drosophila Brain (Thomas Riemensperger, Florian Bilz, André Fiala)....Pages 309-319
Whole-Brain Imaging Using Genetically Encoded Activity Sensors in Vertebrates (Andreas M. Kist, Laura D. Knogler, Daniil A. Markov, Tugce Yildizoglu, Ruben Portugues)....Pages 321-341
Understanding Mood Disorders Using Electrophysiology and Circuit Breaking (He Liu, Dipesh Chaudhury)....Pages 343-370
Combining Anatomy, Measurements and Manipulation of Neuronal Activity to Interrogate Circuit Function in Drosophila (Yvette E. Fisher, Thomas R. Clandinin)....Pages 371-396
Front Matter ....Pages 397-397
Generation of Neuronal Diversity in the Peripheral Olfactory System in Drosophila (Catherine Hueston, Pelin C. Volkan)....Pages 399-418
The Developmental Origin of Cell Type Diversity in the Drosophila Visual System (Claire Bertet)....Pages 419-435
Single-Cell Transcriptomic Characterization of Vertebrate Brain Composition, Development, and Function (Bosiljka Tasic, Boaz P. Levi, Vilas Menon)....Pages 437-468
Transcriptional Profiling of Identified Circuit Elements in Invertebrates (Marta Morey)....Pages 469-506
Front Matter ....Pages 507-507
Perspective: A New Era of Comparative Connectomics (Ian A. Meinertzhagen)....Pages 509-518

✦ Subjects

Medicine;Human genetics;Neurosciences;Cell biology;Biomedicine

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