## Abstract In order to clarify the cellular tropism of human T‐cell leukemia virus type I (HTLV‐I) and the effects of HTLV‐I infection on T‐cell functions, we investigated the infectiousness of HTLV‐I on T cells bearing T‐cell receptor (TCR) γδ and functional alterations of the HTLV‐I‐infected TCR
Decline of natural cytotoxicity of human lymphocytes following infection with human T-cell leukemia/lymphoma virus (HTLV)
✍ Scribed by L. De Vecchis; G. Graziani; B. Macchi; C. Grandori; S. Pastore; M. Popovic; R.C. Gallo; E. Bonmassar
- Book ID
- 113238389
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 449 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0145-2126
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## Abstract Human T‐cell leukemia‐lymphoma virus (HTLV) was first isolated from sporadic patients with adult T‐cell malignancies in the United States and subsequently from T‐lymphocytes established in culture from additional T‐cell leukemia‐lymphoma patients living in different geographical areas o
By co-cultivating peripheral blood lymphocytes from normal male donors with cells from a line designated Lma-66VP. established from a female donor and si- multaneously producing both HTLV-I and EBV, 2 continuous culture lines were obtained. Normal male lymphocytes were considered to be immortalized