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Decitabine (5-Aza-2′-deoxycytidine) decreased DNA methylation and expression of MDR-1 gene in K562/ADM cells

✍ Scribed by Ando, T; Nishimura, M; Oka, Y


Book ID
110054687
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
334 KB
Volume
14
Category
Article
ISSN
0887-6924

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The expression of several cancer-related genes has been reported to be silenced by DNA methylation of their promoter region. 5-Aza-2-deoxycytidine (5-AZA-CdR), a potent and specific inhibitor of DNA methylation, can reactivate the in vitro expression of these genes. In future clinical trials in tumo