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Deciphering the Roles of Trehalose and Hsp104 in the Inhibition of Aggregation of Mutant Huntingtin in a Yeast Model of Huntington’s Disease

✍ Scribed by Chaudhary, Rajeev Kumar; Kardani, Jay; Singh, Kuljit; Banerjee, Ruchira; Roy, Ipsita


Book ID
121603793
Publisher
Humana Press Inc
Year
2013
Tongue
English
Weight
613 KB
Volume
16
Category
Article
ISSN
1535-1084

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## Abstract Patients with Huntington's disease have an expanded polyglutamine tract in huntingtin and suffer severe brain atrophy and neurodegeneration. Because membrane dysfunction can occur in Huntington's disease, we addressed whether mutant huntingtin in brain and primary neurons is present in