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Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme

✍ Scribed by Yitzhak Tor; Thomas Hermann; Eric Westhof

Book ID: 104375759
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 1014 KB
Volume: 5
Category: Article
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(98)90286-1

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✦ Synopsis

Aminoglycoside antibiotics inhibit protein biosynthesis and various ribozymes. Structural electrostatic complementarity can explain the inhibition mechanism of the hammerhead ribozyme: positively charged ammonium groups match the negatively charged metalion-binding pockets created by the RNA fold's electrostatic field.

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