Limits to Catalysis by Ribonuclease A
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J.E. Thompson; T.G. Kutateladze; M.C. Schuster; F.D. Venegas; J.M. Messmore; R.T
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Article
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1995
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Elsevier Science
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English
โ 521 KB
Bovine pancreatic ribonuclease \(\mathrm{A}\) (RNase A) catalyzes the cleavage of the \(\mathrm{P}-\mathrm{O}^{5}\) bond in RNA. Although this enzyme has been the object of much seminal work in biological chemistry, the nature of its rate-limiting transition state and its catalytic rate enhancement