Decarboxylative acylation of thiolmalonate. A model for the biosynthesis of fatty acids and polyketides

✍ Scribed by Yoshiaki Kobuke; Jun-ichi Yoshida

• Publisher: Elsevier Science
• Year: 1978
• Tongue: French
• Weight: 214 KB
• Volume: 19
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)85127-3

✦ Synopsis

In the biosynthesis of fatty acids and polyketides, 1 the malonyl group attached to one of the two sulfhydryl groups (so called "central" SH-group)

in the multienzyme complex is decarboxylatively acylated by the acetyl residue attached to the other ("peripheral" SH-group), giving rise to acetothiolacetate Acetothiolacetate in fatty acid synthesis is then reduced to thiolbutyrate which acts again as an acylating reagent, while in polyketide biosynthesis it directly reacts with malonyl thiolester producing diketoacid thiolester.