Decarboxylation ofl-Dopa by cultured mouse astrocytes
β Scribed by Augusto V. Juorio; Xin-Min Li; Wolfgang Walz; I. Alick Paterson
- Book ID
- 115803877
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 349 KB
- Volume
- 626
- Category
- Article
- ISSN
- 0006-8993
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The present work studied the transport of L-DOPA in cultured rat and mouse astrocytes. Results indicated that the uptake of L-[14C]DOPA in both rat and mouse astrocytes was Na+ independent and temperature sensitive. It was mediated by a carrier-mediated mechanism with K, values of 36 and 60.3 pM, an
## Abstract Nucleotides and nucleosides play important roles by maintaining brain homeostasis, and their extracellular concentrations are mainly regulated by ectonucleotidases and nucleoside transporters expressed by astrocytes. Extracellularly applied NAD^+^ prevents astrocyte death caused by exce