## Abstract Decarboxylation of allylic esters of 4โcarboxypyrimidines in toluene at 111 ยฐC in the presence of a Pd(0) catalyst, gives a mixture of a 4โalkenylpyrimidine and a pyrimidine unsubstituted in the 4โposition. If the decarboxylation is carried out in the presence of benzaldehyde, then benz
Decarboxylation in the Synthesis of 4-Alkyl-, 4-Alkenyl- and 4-Acylpyrimidines.
โ Scribed by Gunnar Herstad; Tore Benneche
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 168 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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Quaternary a-amino acids a b s t r a c t Chiral symmetrical alk-2-yne-1,4-diols have been stereoselectively transformed into 5-alkyl-4-alkenyl-4phenyl-1,3-oxazolidin-2-ones, which are precursors of quaternary a-amino b-hydroxy acids. The key step was the cyclization of the bis(tosylcarbamates) of 2-