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Decarbonylation of α-tertiary amino acids. Application to the synthesis of polyhydroxylated indolizidines

✍ Scribed by Rosa Rodríguez; Francisco Bermejo


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
246 KB
Volume
37
Category
Article
ISSN
0040-4039

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Decarbonylation of α-tertiary amino acid
✍ María J. Martín-López; Rosa Rodriguez; Francisco Bermejo 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 821 KB

The decarbonylation of the bicyclic a-tertiary carboxamido acid 11 led to the enamide 12, easily transformed into the indolizidine alkaloid 8,8a-trans-8-hydroxy-indolizidine 14. Likewise, the same process applied to the ¢t-substituted pipecolic acid derivative 5 led to the unsaturated ester 6 which