Decades of delayed diagnosis in 4 levodopa-responsive young-onset monogenetic parkinsonism patients
✍ Scribed by Helen Ling; Mark Braschinsky; Pille Taba; Siiri-Merike Lüüs; Karen Doherty; Anna Hotter; Werner Poewe; Andrew J. Lees
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 486 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0885-3185
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✦ Synopsis
Abstract
Background:
We report 4 patients with young‐onset monogenetic parkinsonism, each of whom was misdiagnosed with either a psychogenic movement disorder or chronic fatigue syndrome for 10 to 23 years after the onset of their first symptoms.
Results:
Once the diagnosis was eventually made, they all had a rapid and excellent response to levodopa, albeit with the early appearance of interdose dyskinesias in 3.
Conclusions:
We discuss possible reasons for the missed diagnosis despite the relentless progression of their motor handicap. DAT scanning supported the revised clinical diagnosis of parkinsonism. © 2011 Movement Disorder Society