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Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

✍ Scribed by Newell, M. Karen; Haughn, Lori J.; Maroun, Christiane R.; Julius, Michael H.

Book ID
109765894
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
484 KB
Volume
347
Category
Article
ISSN
0028-0836

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## Abstract Although the phenotypic and regulatory properties of the CD4^+^CD25^+^ T cell lineage (Treg cells) have been well described, the specificities remain largely unknown. We demonstrate here that the CD4^+^CD25^+^ Treg population includes the recognition of a broad spectrum of human TCR CDR