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Death of Dopaminergic Neurons in Vitro and in Nigral Grafts: Reevaluating the Role of Caspase Activation

✍ Scribed by Carrie B. Hurelbrink; Richard J.E. Armstrong; Leila M. Luheshi; Stephen B. Dunnett; Anne E. Rosser; Roger A. Barker

Book ID
115607588
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
462 KB
Volume
171
Category
Article
ISSN
0014-4886

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## Abstract We have shown that prothrombin kringle‐2 (pKr‐2), a domain of human prothrombin distinct from thrombin could activate cultured rat brain microglia in vitro. However, little is known whether pKr‐2‐induced microglial activation could cause neurotoxicity on dopaminergic (DA) neurons in viv