✦ LIBER ✦

Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus

✍ Scribed by Mikiya Asako; Avril G. Holt; Ronald D. Griffith; Eric D. Buras; Richard A. Altschuler

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 277 KB
Volume: 81
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.20542

No coin nor oath required. For personal study only.

✦ Synopsis

There is increasing evidence of activity-related plasticity in auditory pathways. The present study examined the effects of decreased activity on immunolocalization of the inhibitory neurotransmitter glycine in the cochlear nucleus of the rat after bilateral cochlear ablation. Specifically, glycine-immunoreactive puncta adjacent to somatic profiles were compared in normal hearing animals and animals deafened for 14 days. The number of glycine-immunoreactive puncta surrounding somatic profiles of spherical and globular bushy cells, glycineimmunoreactive type I stellate multipolar cells, radiate neurons (type II stellate multipolar cells), and fusiform cells decreased significantly. In addition, the number of glycine immunopositive tuberculoventral (vertical or corn) cells in the deep layer of the dorsal cochlear nucleus also decreased significantly. These results suggest that decreased inhibition reported in cochlear nucleus after deafness may be due to decreases in glycine.

📜 SIMILAR VOLUMES

Localization of neurotrophin-3-like immu

Localization of neurotrophin-3-like immunoreactivity in the rat cochlear nucleus

✍ Burette, A.; Belliot, G.; Albuisson, E.; Romand, R. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 760 KB

Immunohistochemistry as well as immunohistofluorescence were used to investigate the distribution of the neurotrophin-3 (NT3) in the adult rat cochlear nucleus. We found a widespread distribution of NT3 immunolabeled neurons throughout the three divisions of this nucleus. NT3-like immunoreactivity w

GABA- and glycine-immunoreactive project

GABA- and glycine-immunoreactive projections from the superior olivary complex to the cochlear nucleus in guinea pig

✍ Ostapoff, E.-Michael; Benson, Christina G.; Saint Marie, Richard L. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 362 KB 👁 2 views

Retrograde transport of horseradish peroxidase was combined with immunocytochemistry to identify the origins of potential g-aminobutyric acid (GABA) -ergic and glycinergic inputs to different subdivisions of the cochlear nucleus. Projection neurons in the inferior colliculus, superior olivary comple

Neuronally modulated transcription of a

Neuronally modulated transcription of a glycine transporter in rat dorsal cochlear nucleus and nucleus of the medial trapezoid body

✍ Barmack, N.H.; Guo, H.; Kim, H.J.; Qian, H.; Qian, Z.-Y. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 779 KB

Neurotransmitter transporters limit transmitter concentration at the postsynaptic membrane by removing neurotransmitters from the synaptic cleft. Not only do neurotransmitter transporters contribute to the regulation of synaptic transmission, but they themselves might be dynamically regulated by neu

GABA-, glycine-, and glutamate-immunorea

GABA-, glycine-, and glutamate-immunoreactive bouton profiles in apposition to neurons of the central cervical nucleus in the rat

✍ Ragnarson, Birger ;Yi, Seong Joon ;Ulfhake, Brun ;Grant, Gunnar 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 992 KB

## Abstract The neurons of the central cervical nucleus (CCN) convey information about the position and movements of the head, and receive excitatory input from dorsal neck muscles and the labyrinth. Both of these afferent sources form glutamatergic synaptic contacts with CCN neurons. However, thes

Glycine immunoreactivity and receptor bi

Glycine immunoreactivity and receptor binding in the cochlear nucleus of C57BL/6J and CBA/CaJ mice: Effects of cochlear impairment and aging

✍ Willott, James F.; Milbrandt, Joseph C.; Bross, Lori Seegers; Caspary, Donald M. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 397 KB 👁 2 views

Glycinergic neurons in the cochlear nucleus (CN) of C57BL/6J (C57) and CBA/CaJ (CBA) mice were studied by using immunocytochemical and receptor-binding techniques. Adult C57 mice exhibit progressive cochlear pathology as they age, whereas aging CBA mice retain good hearing. In the CN of old C57 mice

Axonal pathways to the lateral superior

Axonal pathways to the lateral superior olive labeled with biotinylated dextran amine injections in the dorsal cochlear nucleus of rats

✍ John R. Doucet; David K. Ryugo 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 864 KB

## Abstract The lateral superior olive (LSO) contains cells that are sensitive to intensity differences between the two ears, a feature used by the brain to localize sounds in space. This report describes a source of input to the LSO that complements bushy cell projections from the ventral cochlear