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Deadly Conformations—Protein Misfolding in Prion Disease

✍ Scribed by Arthur L Horwich; Jonathan S Weissman

Book ID: 117267230
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 152 KB
Volume: 89
Category: Article
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80232-9

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more relevant large-animal TSE disease models, these factors make in vivo testing impractical for high-throughput screening. A variety of scrapie-and CWD-infected cell-culture models, and some yeast models [14], have been developed and serve as in vitro surrogates for animal studies in screening fo