Deactivation of macrophages by transforming growth factor-β
✍ Scribed by Tsunawaki, Shohko; Sporn, Michael; Ding, Aihao; Nathan, Carl
- Book ID
- 109755889
- Publisher
- Nature Publishing Group
- Year
- 1988
- Tongue
- English
- Weight
- 475 KB
- Volume
- 334
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/334260a0
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Transforming growth factor-beta1 (TGF-beta) is secreted in a latent form consisting of mature TGF-beta noncovalently associated with its amino-terminal propeptide, which is called latency associated peptide (LAP). Biological activity depends upon the release of TGF-beta from the latent complex follo
Transforming growth factor β 1 (TGF-β 1 ) has been implicated as inhibitor of cell proliferation and a potent inducer of apoptosis in vitro and in vivo after the administration of high doses. To assess the role of endogenous TGF-β 1 , we quantitated the cytokine and its receptors in rat liver during