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Deactivation and desensitization of mouse embryonic- and adult-type nicotinic receptor channel currents

✍ Scribed by K Jahn; B Mohammadi; K Krampfl; A Abicht; H Lochmüller; J Bufler

Book ID
117471858
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
156 KB
Volume
307
Category
Article
ISSN
0304-3940

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Steep concentration dependence and fast desensitization of nicotinic channel currents elicited by acetylcholine pulses, studied in adult vertebrate muscle
✍ C. Franke; H. Hatt; J. Dudel 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 924 KB

Skeletal muscles of adult mice and frogs were dissociated enzymatically and prepared for patchclamping within less than 6 h. Outside-out patches were superfused with repetitive pulses of acetylcholine (ACh) with switching times of about 0.2 ms. Peak responses were reached within 1 ms. In mouse muscl