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Deacetylase inhibitor trichostatin A down-regulates Foxp3 expression and reduces CD4+CD25+ regulatory T cells

✍ Scribed by Zhijian Liu; Chenquan Zhang; Jian Sun


Book ID
116300756
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
433 KB
Volume
400
Category
Article
ISSN
0006-291X

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## Abstract Regulatory T cells (Treg cells) have been well documented to have a crucial physiological role in preventing the development of autoimmune diseases and keeping self‐tolerance. Foxp3, a recently identified member of the forkhead transcription factors, serves as a master regulator for the