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De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats

✍ Scribed by Igor P. Pogribny; S.Jill James


Book ID
117467512
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
243 KB
Volume
187
Category
Article
ISSN
0304-3835

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## Abstract Loss of p16^INK4a^ protein expression has frequently been related to DNA methylation in association with gene silencing. Although the methylation status of exon1Ξ± for p16^INK4a^ involvement in various cancers has been extensively analyzed, it has been pointed out that some inconsistenci