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De novo engineering and metabolic flux analysis of inosine biosynthesis inBacillus subtilis

โœ Scribed by Haojian Li; Guoqiang Zhang; Aihua Deng; Ning Chen; Tingyi Wen

Publisher
Springer Netherlands
Year
2011
Tongue
English
Weight
417 KB
Volume
33
Category
Article
ISSN
0141-5492

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A detailed stoichiometric model was developed for growth and penicillin-G production in Penicillium chrysogenum. From an a priori metabolic flux analysis using this model it appeared that penicillin production requires significant changes in fluxes through the primary metabolic pathways. This is bro