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De novo DNA methylation is required for maintaining genomic and transcriptional integrity in hematopoietic stem cells

✍ Scribed by Challen, Grant; Mayle, Allison; Sun, Deqiang; Jeong, Mira; Luo, Min; Rodriguez, Benjamin; Li, Wei; Goodell, Margaret

Book ID: 122857181
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 52 KB
Volume: 41
Category: Article
ISSN: 0301-472X
DOI: 10.1016/j.exphem.2013.05.053

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## Abstract Transcriptional silencing during differentiation of human male germ cells and serum starvation of human fibroblasts is controlled by epigenetic mechanisms that involve de novo DNA methylation. It is associated with high expression of different trancripts of the DNA methyltransferase 3A