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De Novo Design of Native Proteins: Characterization of Proteins Intended To Fold into Antiparallel, Rop-like, Four-Helix Bundles †

✍ Scribed by Betz, Stephen F.; Liebman, Paul A.; DeGrado, William F.


Book ID
126179327
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
248 KB
Volume
36
Category
Article
ISSN
0006-2960

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## Abstract We investigated the hydrophobic packing of two previously designed caviteins, LG2 and LG3, which differ by one Gly in the linker regions between the peptide sequence and the cavitand scaffold. We sought to diminish the putative native‐like properties of LG2 and LG3, and see if we could