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De Novo Design of a Bolaamphiphilic Peptide with Only Natural Amino Acids

✍ Scribed by Feng Qiu; Yongzhu Chen; Chengkang Tang; Qinghan Zhou; Chen Wang; Ying-Kang Shi; Xiaojun Zhao

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
775 KB
Volume
8
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

A new self‐assembling bolaamphiphilic peptide has been designed and synthesized using only natural amino acids. This simple peptide is composed of two lysines connected by 4–8 alanines to maintain the characteristics of the traditional bolaamphiphiles. Based on an irregular secondary structure, it can self‐assemble into nanospheres, nanorods, or nanofibers with lengths up to micrometers. The long nanofibers can be broken into smaller fragments by sonication, however, they could reassemble into nanofibers after incubation. Furthermore, the nanostructures were shown to have considerable thermostability. This new bolaamphiphilic peptide differs from any other self‐assembling peptides or bolaamphiphiles, and possibly provides a new approach to fabricate nanomaterials.

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