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De novo complex chromosome rearrangement in identical twins with multiple congenital anomalies

✍ Scribed by Yoshiharu Wakita; Kouji Narahara; Kazushiro Tsuji; Yuji Yokoyama; Shinsuke Ninomiya; Ryuko Murakami; Kiyoshi Kikkawa; Yoshiki Seino

Publisher: Springer
Year: 1992
Tongue: English
Weight: 471 KB
Volume: 88
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00219353

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✦ Synopsis

A de novo and apparently balanced complex chromosome rearrangement (CCR) was found in monozygotic (MZ) twin infants with multiple congenital anomalies. The rearrangement involved 4 chromosomes with 6 breakpoints including 2p23, 2q13, 2q21.1, 3p23, 11q13.1, and 12q24.1. This seems to be the first report of a CCR in MZ twins. The relationship between this chromosome abnormality and MZ twinning is discussed.

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