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De novo adipose formation in a vascularized engineered construct

โœ Scribed by Robert L. Walton; Elisabeth K. Beahm; Liza Wu

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
423 KB
Volume
24
Category
Article
ISSN
0738-1085

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โœฆ Synopsis

Abstract

While the field of tissue engineering is a burgeoning one, progress with fat engineering has lagged, due in large part to problems associated with nurturing and sustaining this unique tissue in vivo. In a pilot study using an experimental rat model, we induced liponeogenesis with a combination of Matrigel and basic fibroblast growth factor in an fibrovascular scaffold, isolating the construct to a pedicled blood supply (the superficial inferior epigastric vessels) via a silicone housing, creating an engineered threeโ€dimensional adipose tissue construct. Adipose tissue and vascular ingrowth were assessed histologically and followed by serial study at 4โ€week intervals for 16 weeks. We demonstrated persistence of shaped adipose tissue constructs over time, and postulate that incorporating a vascular supply may enhance the durability of experimentally induced fat constructs and potentially provide a means for microsurgical transfer of the construct. ยฉ 2004 Wileyโ€Liss, Inc.

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