DDT Stimulates c-erbB2, c-met, and STATS Tyrosine Phosphorylation, Grb2-Sos Association, MAPK Phosphorylation, and Proliferation of Human Breast Epithelial Cells

Involvement of tyrosine phosphorylation

Involvement of tyrosine phosphorylation of p185c-erbB2/neu in tumorigenicity induced by x-rays and the neu oncogene in human breast epithelial cells

✍ Kyung-Sun Kang; Wei Sun; Koichiro Nomata; Ikue Morita; Angela Cruz; Chia-Jen Liu 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 1 views

Ionizing radiation is the exogenous agent best proven to induce breast cancer. c-erbB2/neu amplification and overexpression are known to occur in breast cancer and are correlated with aggressive tumor growth and poor prognosis. We have developed simian virus 40-immortalized cell lines from normal hu